ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
CDKN1A	1026	15099969	-	Polymorphism	-	-	285	95	-	-	Department of Obstetrics and Gynecology; Seoul National University Hospital.	IA (n=31); IB (n=34); IC (n=11); IIA (n=5); IIB (n=2); IIIA (n=4); IIIC (n=4); IVB (n=4)	-	[1] There is a significant association between the genetic polymorphisms of p21; and specific combinations of the at-risk genotypes of this gene and the risk of developing endometrial cancer in Korean women. [2] The homozygous carriers of the p21 Ser allele showed a substantially increased risk of developing endometrial cancer (OR 2.68; 95% CI 1.59-4.51) as compared to homozygous and heterozygous carriers of the Arg allele. [3] the combination of the pro allele containing genotypes of p53 and the Ser homozygous genotype of p21 posed a remarkably increased risk (OR 9.55; 95% CI 4.30-21.24) of endometrial cancer development.	p53 and p21 genetic polymorphisms and susceptibility to endometrial cancer	Gynecologic Oncology	93(2):499-505	2004