ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
CDK4	1019	9404701	-	-	-	-	20 (10 proliferative+ 10 secretory)	41	-	-	Shinshu University Hospital	I (n=28); II (n=5); III (n=7); IV (n=1)	1 (n=22); 2 (n=14); 3 (n=5)	[1] Increased expression of nuclear cdk4 associatedwith loss of p16INK4 expression could be involved in the carcinogenesis of asubset of endometrial carcinomas. [2] Topographically;the nuclear cdk4 positive tumor cells were negative for p16INK4 andthe nuclear p16INK4 positive tumor cells were found in areas without nuclear cdk4expression; suggesting an inverse correlation between the two agents.	Immunohistochemical analysis of the expression of cdk4 and p16INK4 in human endometrioid-type endometrial carcinoma.	Cancer	80(12):2250-6	1997
CDK4	1019	10682682	-	-	-	-	-	35 endometrioid type + 18 endometrial hyperplasia + 12 atypical hyperplasia	-	-	-	I (n=23); II (n=5); III (n=6)	-	[1] The expression of CDK4 may be an early event in the neoplastic transformation of endometrial cancer.[2] Strong CDK4 staining was observed in 12 of 35 EC (34.3%) and one of 18 EH (5.6%). The strong expression of CDK4 was higher in EC than in EH (P = 0.0399). The expression of CDK4 was higher in EH than PE (P = 0.0054).	The role of p16-cyclin d/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma.	British Journal of Cancer	82(3):675-82	2000