ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
CDH3	1001	15051772	-	Up regulation/ Over expression/High expression	-	-	-	286	-	-	-	I (n=52); II (n=125); III (n=109)	-	[1] Eighty-three patient samples (30%) showed high membranous expression of P-cadherin; with a significantly higher proportion among the clear-cell or serous papillary type (P = .004). High expression also was associated with high FIGO grade (P < .001); vascular invasion (P = .01); deep myometrial infiltration (P < .001); and increasing FIGO stage (P = .02). [2] Strong P-cadherin expression also was significantly associated with high nuclear grade (P <. 001); solid growth (P = .03); and high mitotic count (P = .01; Mann-Whitney test; data not shown). Among the endometrioid tumors; high P-cadherin expression was significantly associated with high FIGO grade (P = .004); high nuclear grade (P < .001); and deep myometrial infiltration (P = .002).	Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer.	Journal of Clinical Oncology	22(7):1242-52	2004