ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
CDH1	999	12379748	Endometrial Adenocarcinoma and Serous Carcinoma	-	-	-	-	34 (17 Endometrial Adenocarcinoma and 17 Serous Carcinoma)	-	-	-	III (n=17)	-	[1] The expression of E-cadherin in high-grade endometrial cancers is strongly associated with histological subtype. [2] Moderate or strong E-cadherin expression was identified in 7 of 17 (41%) serous carcinomas as opposed to in only 1 of 17 (6%) endometrioid adenocarcinomas (P = .02). [3] [3] There was a tendency of strong -catenin expression being associated with weak E-cadherin expression.	Beta-catenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype	Modern Pathology	15(10):1032-7	2002
CDH1	999	12569599	-	Hypermethylation	-	-	-	-	-	-	Sapporo Medical University Hospital	IA (n=13); IB (n=36); IC (n=19); IIA (n=2); IIB (n=3); IIIA (n=7); IIIB (n=1); IIIC (n=19); IVB (n=3)	1 (n=45); 2 (n=42); 3 (n=11)	[1] Methylation of the E-cadherin gene promoter of endometrial carcinoma and the evidence suggests that methylation of the E-cadherin gene occurs in association with the acquisition of invasive capacity. [2] In G1 endometrial adenocarcinomas; 66.7% showed positive staining and 33.3% showed heterogeneous staining. Methylation of the E-cadherin gene was detected in 15.6%. In G2 tumors; 19.0% showed positive staining; 69.0% showed heterogeneous staining and 11.9% showed negative staining. Methylation of the E-cadherin gene was found in 50.0%. In G3 tumors; 9.1% showed positive staining; 54.5% showed heterogeneous staining and 36.3% showed negative staining. Methylation of the E-cadherin gene was found in 81.8% of the tumors. Of the samples with no-myometrial invasion; 23.1% had methylation. In those with invasion in less than half of the myometrium; 28.6% did and in those with invasion of half or more of the myometrium; 55.6% had methylation. Of samples that did not have lymph node metastasis; 33.7% had methylation; whereas of samples that had lymph node metastasis; 60.0% had methylation.	Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma.	Cancer	97(4):1002-9	2003
CDH1	999	15051772	-	Down regulation/ Down expression	-	-	-	286	-	-	-	I (n=52); II (n=125); III (n=109)	-	[1] Reduced or low membranous expression of E-cadherin(n=159; 56%) was significantly associated with the serousor papillary type (P=0.002); high FIGO grade (P=0.04);vascular invasion (P=0.04); deep myometrial invasion (50%; P=0.002); and high FIGO stage (P=0.001);Low E-cadherin expression was also associatedwith high nuclear grade (P=0.002); solid growth more than50% (P=0.001); diffusely infiltrative growth pattern (P=0.001); and high mitotic count (P=0.003)	Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer.	Journal of Clinical Oncology	22(7):1242-52	2004