ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
CASP7	840	19531679	-	Polymorphism	-	-	1003	1028	-	54.3 (for case) 54.4 (for control)	Sanghai; China	-	-	[1] Four SNP in the caspase-7 gene were in high linkage diequilibrium (rs11593766; rs3124740; rs11196445 and rs11196418) and associated with the risk for endometrial cancer. [2] The AA genotype of rs11196418 [odds ratio; 0.36; 95% confidence interval (95% CI); 0.14-0.94] and the G allele of rs11593766 were associated with reduced risk (odds ratio of 0.75 and 95% CI of 0.59-0.96 for carriers of one G allele; odds ratio of 0.70 and 95% CI of 0.24-2.03 for carriers of two G alleles). The AA genotype of rs11196445 (odds ratio; 1.74; 95% CI; 0.99-3.05); the CC genotype of rs3124740 (odds ratio; 1.36; 95% CI; 1.06-1.75); and the GG genotype of rs10787498 in the caspase-7 gene (odds ratio; 1.90; 95% CI; 1.16-3.11) were associated with increased risk compared with homozygotes of the major alleles.	Polymorphisms and haplotypes in the caspase-3; caspase-7; and caspase-8 genes and risk for endometrial cancer: a population-based; case-control study in a Chinese population	Cancer epidemiology; biomarkers & prevention	18(7):2114-22	2009