| CASC2 | 255082 | 17352238 | - | Down regulation/ Down expression | - | Tumor suppressor | - | - | - | - | "Sassari University and Azienda Unità Sanitaria Locale of Sassari | Italy" | - | | "[1] A significantly decreased level of CASC2a transcripts was observed in 13/17 (76%) EC tissues. [2] Exogenous expression of CASC2a in undifferentiated AN3CA endometrial cancer cells inhibited cellular growth in anchorage-independent growth assays indicating that CASC2A may excert a high potential for negative regulation of clonal growth. [3] CASC2a may act as a tumour suppressor gene | with both epigenetic and genetic alterations concurring to gene inactivation. Down-regulation of CASC2a may provide a growth advantage in EC cells. [4] CASC2a mRNA levels were markedly reduced (with a down-regulation of at least 79%) in all EC+SD tumours." | CASC2a gene is down-regulated in endometrial cancer. | 0 |