ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
APC	324	12097272	-	Hypermethylation	-	Tumor suppressor	-	114	-	-	University of Toronto	-	-	[1] APC hypermethylation occurs at an increased frequency in MSI+ endometrial tumors (P = 0.01).Methylation of APC is also observed at the earliest stages of endometrial tumorigenesis; including simple; complex; and atypical hyperplasias. [2] Tumor-specific hypermethylation of APC with corresponding unmethylated normal endometrial tissue occurred in 43% (17 of 40) of MSI+ cases (P = 0.0007) and 16% (12 of 74) of microsatellite stable cases (P = 0.04). Interestingly; tumor tissue was unmethylated with normal tissue displaying APC methylation in 4% (5 of 114; 2MSI+ and 3 microsatellite stable) of cases.	Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype	Cancer Research	62(13):3663-6	2002