ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
AKT1	207	11309338	-	-	-	-	-	103	-	-	Tottori University Hospital Yonago; Japan	-	-	[1] Akt activation accompained by PTEN activation is a key step in the development and/or progression of carcinomas. [2] A significant inverse correlation between PTEN and phospho-Akt (r = -0.796). The phospho-Akt level in negative immunohistochemical staining of PTEN cases is significantly higher. [3] The study demonstrates the phosphorylation of Akt is accompanied by the loss of PTEN in clinical specimens of endometrial carcinomas.	Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma.	Clinical Cancer Research	7(4):892-5	2001
AKT1	207	12790783	-	-	-	-	-	-	-	-	-	IIIC (n=55); IV (n=9)	1 (n=21); 2 (n=25); 3 (n=18)	[1] The phosphorylation of Akt accompanied by the loss of PTEN in clinical specimens of endometrial cancers. Akt was signi?cantly phosphorylated in tumor tissue with loss of PTEN expression; and that phosphorylated Akt expression was negatively correlated with PTEN expression. This ?nding supports the basic evidence that Akt activation accompanied by PTEN inactivation is a key step for the development and/or progression of cancer.	Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer	Endocrine-related Cancer	10(2):203-8	2003