ECDB-Endometrial cancer gene database

REFERENCES

Gene Name	Gene ID	Pubmed ID	Classification	Mechanism	Marker	Type	Normal Cases	Disease Cases	Age	Mean Age	Place	FIGO	Grade	Remark	Title	Journal	Volume	Year
ABCB1	5243	17300681	-	Mutation	-	-	198+488 healthy volunteers	198	-	64.9 (disease); 64.8 (control); 39.2 (volunteers)	-	-	-	[1] MDR1 C3435T polymorphism is correlated with endometrial cancer susceptibility. [2] Genotypes containing at least one 3435T allele were statistically significant more frequent in the endometrial cancer group (86.8% vs 75.2%; OR 2.18; P = 0.004). [3] The distribution of MDR1 3435 genotypes was significantlydifferent between cases and controls (P ¼ 0.006).Genotypes containing at least one 3435T allele were statisticallysignificant more frequent in the endometrialcancer group (86.8% vs 75.2% in controls; OR 2.18; P ¼0.004). The overrepresentation of homozygous 3435TTgenotypes in endometrial cancer group (31.3% vs22.2%) and slight overrepresentation of heterozygous3435CT in this group (55.6% vs 53.0%) were observed;however; did not reach statistical significance.; Analysisof alleles frequency showed significant overrepresentationof 3435T allele in endometrial cancer group(P ¼ 0.004).	The significance of C3435T point mutation of the MDR1 gene in endometrial cancer.	International Journal of Gynecological Cancer	17(3):728-31	2007