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ID PMID Sequence Chirality Peptide name Origin Family Nature Sub-cellular localization N terminal modification C terminal modification Uptake efficiency Uptake mechanism Cancer cell lines Patent number
120221319732RQIKIWFQNRRMKWKKLPenetratin (pAntp) Antennapedia homeodomain of drosophilaProtein derivedAmphipathic VesiclesLabelled with K-FITC or k-FITC at N-terminusFreeLower than CyLoP1Probably endocytic processNIH-3T3 Unknown
120321319732rkkrrqrrrDTat (49-57)HIV-1Protein derivedCationic VesiclesLabelled with K-FITC or k-FITC at N-terminusFreeLower than CyLoP1Probably endocytic processNIH-3T3 Unknown
120421319732rrrqrrkkrDTat (57-49)HIV-1Protein derivedCationic VesiclesLabelled with K-FITC or k-FITC at N-terminusFreeLower than CyLoP1Probably endocytic processNIH-3T3 Unknown
120521319732rrrrrrrrDR8Positively charged sequenceSyntheticCationic VesiclesLabelled with K-FITC or k-FITC at N-terminusFreeLower than CyLoP1Probably endocytic processNIH-3T3 Unknown
138117984975MVRRFLVTLRIRRACGPPRVRVLARF(1-22)P14ARF proteinProtein derivedUnknownPunctual/vesicular distribution (vesicles)Labelled with fluoresceinAmidationHigh, comparable to that of TP10Endocytic pathwayMCF-7 and MDA MB 231 Unknown
138217984975FVTRGCPRRLVARLIRVMVPRRLARF(1-22) scrP14ARF proteinProtein derivedUnknownPunctual/vesicular distribution (vesicles)Labelled with fluoresceinAmidationComparable to ARF (1-22)Endocytic pathwayMCF-7 and MDA MB 231 Unknown
140719858187KCFQWQRNMRKVRGPPVSCIKRLhLF peptideHuman lactoferin (hLF) (38–59)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationHigh and comparable to Tat (48-60) and penetratin UnknownHeLa and rat IEC-6 cellsUnknown
140819858187KCFQWQRNMRKVRGPPVSC LM1Human lactoferin (hLF)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationSligltly lesser the hLF peptideUnknownHeLa Unknown
140919858187KCFQWQRNMRKVRGPPVSSIKRLM2Human lactoferin (hLF)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationLower than hLF peptideUnknownHeLa Unknown
141019858187KCFQWQRNMRKVRLM3Human lactoferin (hLF)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationLower than hLF peptideUnknownHeLa Unknown
141119858187FQWQRNMRKVRGPPVSLM4Human lactoferin (hLF)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationLower than hLF peptideUnknownHeLa Unknown
141219858187QWQRNMRKVRGPPVSCIKRLM5Human lactoferin (hLF)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationLower than hLF peptideUnknownHeLa Unknown
141319858187QWQRNMRKVRLM6Human lactoferin (hLF)Protein derivedUnknownVesicles at low concentartion and cytoplasm and nucleus at high concentartLabelled with fluoresceineAmidationLower than hLF peptideUnknownHeLa Unknown
141619858187KCFMWQEMLNKAGVPKLRCARKLrLFRat lactoferin (hLF)Protein derivedUnknownVesiclesLabelled with fluoresceineAmidationVery less uptake was observedUnknownHeLa and IEC-6 cellsUnknown
143021365733VELPPPVELPPPVELPPPLSweet Arrow Protein (SAP) (E)Maize gamma-ZeinProtein derivedAmphipathic Punctuated distribution (vesicles)Labelled with fluoresceine/ rhodamine FreeComparable to L-SAPLipid raft caveolae mediated endocytic processHeLa, A549, BJ and HT cellsUnknown
144717622242MVTVLFRRLRIRRACGPPRVRVLM918C-terminus of p14ARF proteinProtein derivedAmphipathic VesiclesLabelled with fluoresceineAmidationHigher than PenetratinMainly via endocytic process,and in particular macropinocytosis, but independent of glycosaminoglycans on the cell surfaceHeLa, MCF-7, CHO K1, and Hifko cellsUnknown
145815290867LGTYTQDFNKFHTFPQTAIGVGAPLhCT (9–32)Human calcitonin (hCT)Protein derivedUnknownBoth punctuated cytoplasmic (vesicles) and extracellular distribution Labelled with fluoresceineAmidationUnknownUnknownTR146 cellsUnknown
145915290867YTQDFNKFHTFPQTAIGVGAPLhCT(12–32)Human calcitonin (hCT)Protein derivedUnknownCytoplasmic and punctuated pattern (vesicles)Labelled with fluoresceineAmidationUnknownUnknownMDCK cellsUnknown
146315290867GYGRKKRRQRRRGLTat (47-57)HIV-1Protein derivedCationic Cytoplasmic and punctuated pattern (vesicles)Carries an extra glycine and labelled with fluoresCarries an extra glycineUnknownCondition dependent (not determined in this paper)MDCK cellsUnknown
146415290867GYGRKKRRQRRRGLTat (47-57)HIV-1Protein derivedCationic Punctuated cytoplasmic (vesicles) as well as extracellular stainingCarries an extra glycine and labelled with fluoresCarries an extra glycineUnknownCondition dependent (not determined in this paper)Calu-3 cellsUnknown
146615290867RQIKIWFQNRRMKWKKLPenetratin {pAntp-(43–58)}Antennapedia homeodomain of drosophilaProtein derivedAmphipathic Surface of the plasma membrane and intracellular vesiclesLabelled with fluoresceineAmidationUnknownUnknownMDCK cellsUnknown
146715290867RQIKIWFQNRRMKWKKLPenetratin {pAntp-(43–58)}Antennapedia homeodomain of drosophilaProtein derivedAmphipathic Punctuated cytoplasmic (vesicles) as well as extracellular stainingLabelled with fluoresceineAmidationUnknownUnknownCalu-3 cellsUnknown
146815290867RQIKIWFQNRRMKWKKLPenetratin {pAntp-(43–58)}Antennapedia homeodomain of drosophilaProtein derivedAmphipathic Punctuated cytoplasmic pattern (vesicles)Labelled with fluoresceineAmidationUnknownUnknownTR146 cellsUnknown
148012783857RGGRLSYSRRRFSTSTGRLSynB1protegrinProtein derivedAntimicrobial Endocytic vesiclesLabelled with NBD and TAMRA FreeLower than pAntp-(43–58) and SynB5Adsorptive-mediated endocytic processK562 cellsUnknown
148212783857RRLSYSRRRFLSynB3protegrinProtein derivedAntimicrobial Endocytic vesiclesLabelled with NBD and TAMRA FreeLower than pAntp-(43–58) and SynB5Adsorptive-mediated endocytic processK562 cellsUnknown
148412783857RGGRLAYLRRRWAVLGRLSynB5protegrinProtein derivedAntimicrobial Endocytic vesiclesLabelled with NBD and TAMRA FreeLower than pAntp-(43–58) Adsorptive-mediated endocytic processK562 cellsUnknown
148512783857RQIKIWFQNRRMKWKKLPenetratin {pAntp-(43–58)}Antennapedia homeodomain of drosophilaProtein derivedAmphipathic Endocytic vesiclesLabelled with NBD and TAMRA FreeUnknownAdsorptive-mediated endocytic processK562 cellsUnknown
1506UnknownGLRKRLRKFRNKIKEKLSc18CAMP cathelicidin (106-121)Protein derivedCationic amphipathic VesiclesLabelled with fluoresceineAmidationHighEnergy-dependent endocytic pathwayHeLa, HEK 293 and MCF-7 Unknown
150915054781VRLPPPLPolyP 1Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151015054781VRLPPPVRLPPPLPolyP 2Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151115054781VRLPPPVRLPPPVRLPPPLPolyP 3 (SAP)Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeHighEndocytic pathwayHeLa Unknown
151215054781VHLPPPLPolyP 4Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151315054781VHLPPPVHLPPPLPolyP 5Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151415054781VHLPPPVHLPPPVHLPPPLPolyP 6Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151515054781VKLPPPLPolyP 7Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151615054781VKLPPPVKLPPPLPolyP 8Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeLowProbably endocytic pathwayHeLa Unknown
151715054781VKLPPPVKLPPPVKLPPPLPolyP 9Maize gamma-ZeinProtein derivedAmphipathic Punctate cytoplasmic distribution (vesicles)Labelled with fluoresceineFreeMedium Probably endocytic pathwayHeLa Unknown
179521873420GGVCPKILKKCRRDSDCPGACICRGNGYCGSGSDL & CMCoTI-II(MCo) Momordica cochinchinensis trypsin inhibitor IIProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
179621873420GGVCPKILAACRRDSDCPGACICRGNGYCGSGSDL & CMCoKKAA double mutantMomordica cochinchinensis trypsin inhibitor IIProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
179721873420GGVCPAILKKCRRDSDCPGACICRGNGYCGSGSDL & CMCoK6A mutantMomordica cochinchinensis trypsin inhibitor IIProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
179821873420GGVCPKILAKCRRDSDCPGACICRGNGYCGSGSDL & CMCoK9A mutantMomordica cochinchinensis trypsin inhibitor IIProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
179921873420GGVCPKILKACRRDSDCPGACICRGNGYCGSGSDL & CMCoK10A mutantMomordica cochinchinensis trypsin inhibitor IIProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
180021873420GLPVCGETCVGGTCNTPGCKCSWPVCTRNL & CkT20K mutantO. affinisProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
180121873420GLPVCGETCVGGTCNTPGCTCSWPKCTRNL & CkV25K mutantO. affinisProtein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
180221873420GRCTKSIPPICFPDL & CSFTI-1Sunflower trypsin inhibitor 1Protein derivedUnknownEndosomal compartments (vesicles)Lysine rsidue labeled with Alexa-488CyclizationUnknownEndocytic pathwayRAW 264.7 and MCF-7 Unknown
181221867915RRRRRRRRRLR9Positively charged sequenceSyntheticCationic Vesicles and cytosol Fluorescein labelledAmidationGreater than r9UnknownMC57 Unknown
181821867915rRRRRRRRrMChimeric r (1-9)Positively charged sequenceSyntheticCationic VesiclesFluorescein labelledAmidationUnknownUnknownMC57 Unknown
182021867915RQIKIWFQNRRMKWKKLPenetratin {pAntp-(43–58)}Antennapedia homeodomain of drosophilaProtein derivedAmphipathic VesiclesFluorescein labelledAmidationUnknownUnknownHeLa Unknown
182221867915rqikiwfqnrrmkwkkDPenetratin {pAntp-(43–58)}Antennapedia homeodomain of drosophilaProtein derivedAmphipathic Vesicles and membrane boundFluorescein labelledAmidationUnknownUnknownHeLa Unknown
182421867915KCFQWQRNMRKVRGPPVSCIKRLhLF(38–59) peptideHuman lactoferineProtein derivedUnknownVesicles and membrane boundFluorescein labelledAmidationUnknownUnknownHeLa Unknown
182521867915KCFQWQRNMRKVRGPPVSCIKRLhLF(38–59) peptideHuman lactoferineProtein derivedUnknownVesicles and membrane boundFluorescein labelledAmidationUnknownUnknownMC57 Unknown
183019733192GGGARKKAAKAARKKAAKAARKKAAKAARKKAAKALPODDesignedSyntheticUnknownPunctate pattern (vesicles) FreeGFPUnknownEndocytic pathways but more than one mechanism may possibleHuman embryonic retinoblasts, A549 Unknown
183119707187GRKKRRQRRRPPQCLHIV-1 Tat (48–60)HIV-1Protein derivedCationic Only punctate distribution (vesicles)FreeAlexa 488 labeling at glycyl cysteine sequenceUnknownEndocytic pathway (Macropinocytosis)CHO-K1, HeLa and Jurkat US 20040132970
183319707187RRRRNRTRRNRRRVRGCLFHV coat (35–49)Flock House VirusProtein derivedCationic Punctate distribution (vesicles) with diffuse flurescence in cytosole and FreeAlexa 488 labeling at glycyl cysteine sequence2.7–6.4 times more than the Rev peptideEndocytic pathway (Macropinocytosis)CHO-K1, HeLa and Jurkat Unknown
184212411431GRKKRRQRRRPPLTat (48-59)HIV-1Protein derivedCationic Punctate distribution (vesicles) Fluorescein-taggedFreeUnknownEnergy dependent endocytic pathwayHeLa and CHO K1 and Jurkat Unknown
184312411431RRRRRRRRRLR9Positively charged sequenceSyntheticCationic Punctate distribution (vesicles) Fluorescein-taggedFreeUnknownEnergy dependent endocytic pathwayHeLa Unknown