| ID |
PMID |
Sequence |
Chirality |
Peptide name |
Origin |
Family |
Nature |
Sub-cellular localization |
N terminal modification |
C terminal modification |
Uptake efficiency |
Uptake mechanism |
Cancer cell lines |
Patent number |
|
| 1006 | 11087855 | RKKRRQRRR | L | Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | High | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1007 | 11087855 | RKKRRQRR | L | Tat (49-56) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Medium (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1008 | 11087855 | RKKRRQR | L | Tat (49-55) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1009 | 11087855 | KKRRQRRR | L | Tat (50-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1010 | 11087855 | KRRQRRR | L | Tat (51-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1011 | 11087855 | rkkrrqrrr | D | D-Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | High (greater than Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1012 | 11087855 | RRRQRRKKR | L | Retro - Tat (57-49) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | High (greater than Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1013 | 11087855 | rrrqrrkkr | D | D-Tat (57-49) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | High (greater than Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1014 | 11087855 | AKKRRQRRR | L | Ala49 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1015 | 11087855 | RAKRRQRRR | L | Ala50 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1016 | 11087855 | RKARRQRRR | L | Ala51 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1017 | 11087855 | RKKARQRRR | L | Ala52 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1018 | 11087855 | RKKRAQRRR | L | Ala53 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1019 | 11087855 | RKKRRARRR | L | Ala54 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Medium (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1020 | 11087855 | RKKRRQARR | L | Ala55 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1021 | 11087855 | RKKRRQRAR | L | Ala56 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1022 | 11087855 | RKKRRQRRA | L | Ala57 substitution mutant of Tat (49-57) | HIV-1 | Protein derived | Cationic | Probably cytoplasm and nucleus, nucleolus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1031 | 11087855 | RRRRR | L | R5 | Positively charged sequence | Synthetic | Cationic | Cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1032 | 11087855 | RRRRRR | L | R6 | Positively charged sequence | Synthetic | Cationic | Cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | Medium (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1033 | 11087855 | RRRRRRR | L | R7 | Positively charged sequence | Synthetic | Cationic | Cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1034 | 11087855 | RRRRRRRR | L | R8 | Positively charged sequence | Synthetic | Cationic | Cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1035 | 11087855 | RRRRRRRRR | L | R9 | Positively charged sequence | Synthetic | Cationic | Cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1039 | 11087855 | rrrrr | D | D-R5 | Positively charged sequence | Synthetic | Cationic | Probably cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | Low (relative to Tat (49-57)) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1040 | 11087855 | rrrrrr | D | D-R6 | Positively charged sequence | Synthetic | Cationic | Probably cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (comparable to Tat (49-57) and higher than R6 | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1041 | 11087855 | rrrrrrr | D | D-R7 | Positively charged sequence | Synthetic | Cationic | Probably cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (relative to both Tat (49-57) and R7) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1042 | 11087855 | rrrrrrrr | D | D-R8 | Positively charged sequence | Synthetic | Cationic | Probably cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (relative to both Tat (49-57) and R7) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1043 | 11087855 | rrrrrrrrr | D | D-R9 | Positively charged sequence | Synthetic | Cationic | Probably cytoplasm and nucleus | Labelled with fluorescein with aminohexanoic space | Free | High (relative to both Tat (49-57) and R7) | Probably non-endocytic pathway | Jurkat | US 6593292 |
|
| 1218 | 21359136 | VPTLK | L | Bip2 | Bax-binding domain of mouse Ku70 | Protein derived (Cell penetrating pentapeptides) | Unknown | Cytosole | Labelled with fluorescein | Free | Medium (61% of KLPVM) | Mechanisms other than endocytic and pinocytic process (Non-endocytic pathway) | DAMI, Jurkat, CHO A745, CHO K1, and HeLa | Unknown |
|
| 1262 | 19956900 | KLWMRWYSPTTRRYG | L | No.14 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Greater than Tat peptide | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1263 | 19956900 | DSLKSYWYLQKFSWR | L | No.15 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Greater than Tat in CHO cells, while slightly infe | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1264 | 19956900 | RTLVNEYKNTLKFSK | L | No.63 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1265 | 19956900 | IPSRWKDQFWKRWHY | L | No.143 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells, greater | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1266 | 19956900 | GYGNCRHFKQKPRRD | L | No. 440 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1267 | 19956900 | KNAWKHSSCHHRHQI | L | No. 2028 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells, Greater | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1268 | 19956900 | RVREWWYTITLKQES | L | No. 2175 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells, Greater | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1269 | 19956900 | QQHLLIAINGYPRYN | L | No. 2510 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells, Greater | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1270 | 19956900 | WKCRRQCFRVLHHWN | L | JF06 | In vitro virus (IVV) library | Synthetic | Amphipathic | Unknown | Labelled with fluorescein | Free | Similar or greater than TAT in CHO cells | Unknown | HeLa, Jurkat and CHO | Unknown |
|
| 1813 | 21867915 | RRRRRRRRR | L | R9 | Positively charged sequence | Synthetic | Cationic | Cytoplasm | Fluorescein labelled | Amidation | Greater than r9 | Unknown | Jurkat | Unknown |
|
| 1816 | 21867915 | rrrrrrrrr | D | r9 | Positively charged sequence | Synthetic | Cationic | Cytoplasm and nucleoli | Fluorescein labelled | Amidation | Comparable to R9 | Unknown | Jurkat | Unknown |
|
| 1831 | 19707187 | GRKKRRQRRRPPQC | L | HIV-1 Tat (48–60) | HIV-1 | Protein derived | Cationic | Only punctate distribution (vesicles) | Free | Alexa 488 labeling at glycyl cysteine sequence | Unknown | Endocytic pathway (Macropinocytosis) | CHO-K1, HeLa and Jurkat | US 20040132970 |
|
| 1832 | 19707187 | TRQARRNRRRRWRERQRGC | L | HIV-1 Rev (34–50) | HIV-1 | Protein derived | Cationic | Unknown | Free | Alexa 488 labeling at glycyl cysteine sequence | 2.5–6.6 times more than the Tat (48–60) peptid | Unknown | CHO-K1, HeLa and Jurkat | Unknown |
|
| 1833 | 19707187 | RRRRNRTRRNRRRVRGC | L | FHV coat (35–49) | Flock House Virus | Protein derived | Cationic | Punctate distribution (vesicles) with diffuse flurescence in cytosole and | Free | Alexa 488 labeling at glycyl cysteine sequence | 2.7–6.4 times more than the Rev peptide | Endocytic pathway (Macropinocytosis) | CHO-K1, HeLa and Jurkat | Unknown |
|
| 1834 | 19707187 | KMTRAQRRAAARRNRWTARGC | L | BMV Gag (7–25) | RNA/DNA binding peptide | Protein derived | Cationic | Unknown | Free | Alexa 488 labeling at glycyl cysteine sequence | Less than Tat | Unknown | CHO-K1, HeLa and Jurkat | Unknown |
|
| 1835 | 19707187 | TRRQRTRRARRNRGC | L | HTLV-II Rex (4–16) | RNA/DNA binding peptide | Protein derived | Cationic | Unknown | Free | Alexa 488 labeling at glycyl cysteine sequence | Less than Tat | Unknown | CHO-K1, HeLa and Jurkat | Unknown |
|
| 1836 | 19707187 | RIKAERKRMRNRIAASKSRKRKLERIARGC | L | Human cJun (252–279) | RNA/DNA binding peptide | Protein derived | Cationic | Unknown | Free | Alexa 488 labeling at glycyl cysteine sequence | Greaterv than Tat and Rev but less than FHV | Unknown | CHO-K1, HeLa and Jurkat | Unknown |
|
| 1837 | 19707187 | KRRIRRERNKMAAAKSRNRRRELTDTGC | L | Human cFos (139–164) | RNA/DNA binding peptide | Protein derived | Cationic | Unknown | Free | Alexa 488 labeling at glycyl cysteine sequence | Less than Tat | Unknown | CHO-K1, HeLa and Jurkat | Unknown |
|
| 1842 | 12411431 | GRKKRRQRRRPP | L | Tat (48-59) | HIV-1 | Protein derived | Cationic | Punctate distribution (vesicles) | Fluorescein-tagged | Free | Unknown | Energy dependent endocytic pathway | HeLa and CHO K1 and Jurkat | Unknown |
