| Gene Name |
Pubmed ID |
Classification |
Sample Location |
Remark |
| RASSF1 | 17971771 | Methylation | VU University Medical Center in Amerstdam | RASSF1A is significantly more frequently methylated in adenocarcinomas with 37.5% frequency. |
| RASSF1 | 18608185 | Methylation | Department of Gynecology, JawaharLal Nehru Medical College and Hospital, Aligarh | Aberrant methylation of RASSF1A gene is found in 35% of cases of cervix cancer. |
| RASSF1 | 19469170 | - | Department of Pathology of Cancer Hospital, Shanxi. | Microsatellite alterations of RASSF1A gene is significant for cervical cancer. RASSF1A gene change is a relatively late event in cervical carcinoma. |
| RASSF1 | 17360030 | Methylation | National Cancer Center, Korea and Cheil Hospital, Korea | Genetic or epigenetic alteration in RAS pathway including a mutation in RASSF1A methylation has been reported to play an important role in cervical cancer development. |
| RASSF1 | 15612586 | Methylation | Division of Pathological Anatomy of Human Tumors of Blokhin Cancer Research Center, Russian Academy of Medical Sciences. | RASSF1A gene is methylated in in genesis of tumor of cervical and its expression level increses with tumor progression |
| RASSF1 | 12912945 | Methylation | Samsung Cheil Hospital, Seoul, Korea | Hypermethylation of the RASSF1A promoter region is common in adenocarcinoma of the uterine cervix and rare in squamous carcinoma of uterine cervix. And methylation of promoter has been found in 45% of AC> |
| RASSF1 | 12702579 | Methylation | - | Presence of HPVs in cervical carcinoma may alleviate the requirement for RASSF1A inactivation, a tumor suppressor gene. RASSF1A promoter is methylated in 10% of squamous cell carcinomas, 21% of adenocarcinoma and 24% of cervical adenocarcinoma. |
| RASSF1 | 12673680 | Methylation | - | Hypermethylation of tumor suppressor gene RASSF1A occurs in cervical cancer in which concomitant loss of heterozygosity at 3p21 is common.Hypermethylation of RASSF1A is detected in 30% of SCC and 12% of AC. |
| RASSF1 | 16331610 | Methylation | Gynecologic Oncology Division of Seoul National University Hospital | This gene is more methylated in AC than SCC (9.7%,P=0.008) |
| RASSF1 | 17097722 | Methylation | Tri-Service General Hospital, Taiwan | In AC, the promoter of RASSF1A is hypermethylated in 26.1% of patients, which indicates that RASSF1A hypermethylation may play an essential role in cervical adenocarcinoma. |
| RASSF1 | 15948711 | Methylation | - | There is an inverse correlation between methylation of RASSF1A and HPV. |
| RASSF1 | 19836067 | Methylation | Chonnam National University Hwasun Hospital | The trend of methylation of this gene is increasing with increasing severity of cervical squamous lesions (p<0.001). |
| RASSF1 | 15589597 | Methylation | Department of Obstertics and Gynecology, Seoul national University Hospital. | Frequency of methylation of this gene is found to be 12.2%. |
| RASSF1 | 17097722 | Methylation | - | The RASSF1A was methylated in 15% of SCC, 17.5% of HSIL, but not in LSIL or normal tissues (P<0.001). In AC, 43.5% of patients showed BLU methylation and 26.1% RASSF1A methylation |
| RASSF1 | 12773202 | Methylation | - | high frequency of promoter methylation in CDH1, DAPK, RARB, and HIC1 genes |