| Primary information |
|---|
| sequence ID | Seq_2868 |
| Peptide sequence | GLPGPPDVPDHAAYHPF |
| CancerPDF_ID | CancerPDF_ID49, CancerPDF_ID1060, CancerPDF_ID1862, CancerPDF_ID8570, |
| PMID | 16896061,16395409,21136997,23667664 |
| Protein Name | Inter-alpha-trypsin inhibitor heavy chain H7,Inter-alpha-trypsin inhibitor heavy chain H5,Inter-alpha-trypsin inhibitor heavy chain H4,Inter-alpha-trypsin inhibitor heavy chain H4 |
| UniprotKB Entry Name | ITIH4_HUMAN,ITIH4_HUMAN,ITIH4_HUMAN,ITIH4_HUMAN |
| Fluid | Serum,Serum,Serum,Serum |
| M/Z | 1786.86,1786.86,1785.84747,1785.85 |
| Charge | 1,1,1,1 |
| Mass (in Da) | 1786.85,NA,NA,1787.97 |
| fdr | NA,NA,NA,NA |
| Profiling Technique | MALDI-TOF,MALDI-TOF,LC-MS,MALDI-TOF |
| Peptide Identification technique | Q/TOF MS/MS,Q/TOF/TOF and LC-MS/MS,LC-MS-MS/MS,FT-ICR MS/MS + nano-HPLC |
| Quantification Technique | NA,NA,LC-ESI-MS,NA |
| Labelled/Label Free | Label Free,Label Free,Label Free,Label Free |
| FDR | NA,less than 1 “5,NA,NA |
| CancerPDF_ID | CancerPDF_ID49, CancerPDF_ID1060, CancerPDF_ID1862, CancerPDF_ID8570, |
| p-Value | 1.00E-05,less than 0.01,NA,NA |
| Software | MASCOT,MASCOT (v 2.0.04 for Windows),MASCOT(v. 2.2.01),MASCOT |
| Length | 17,17,17,17 |
| Cancer Type | Metastatic thyroid carcinomas,"Advanced Prostate, Breast and Bladder cancer",Colorectal cancer,"Breast cancer, Lung cancer, Rectal cancer" |
| Database | NCBI refseq Protein Database,NCBI refseq Protein Database,SwissProt Database,NA |
| Modification | NA,NA,NA,NA |
| Number of Patients | 40 metastatic thyroid carcinoma patients and 40 normal for training phase and 10 metastatic thyroid carcinoma and 10 normal individuals for independent validation,"Advanced prostate (n = 32), breast (n = 21), and bladder (n = 20) cancer, 33 healthy in training test set, In validation set 41 independent serum samples from patients with advanced prostate cancer (prostate 2 [PR2])",30 patients and 30 healthy controls,"Breast Cancer =84, lung cancer= 70, Rectal cancer = 30patients; 500 healthy" |
| Regulation | NA,"Upregulated in cancer vs normal with Ratio of median intensity (patients/Controls) =2.39, 2.88 and 2.3 in prostate, bladder and breast cancer respectively",NA,NA |
| Validation | Independent validation,Independent validation,Leave One out Cross validation,NA |
| Sensitivity | 95% on independent dataset,97.5% on independent validation dataset,NA,NA |
| Specificity | 95% on independent dataset,NA,NA,NA |
| Accuracy | NA,97.5 % on validation dataset,NA,NA |
| Peptide Atlas | PeptideAtlas |
| IEDB | |