Primary information |
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sequence ID | Seq_2868 |
Peptide sequence | GLPGPPDVPDHAAYHPF |
CancerPDF_ID | CancerPDF_ID49, CancerPDF_ID1060, CancerPDF_ID1862, CancerPDF_ID8570, |
PMID | 16896061,16395409,21136997,23667664 |
Protein Name | Inter-alpha-trypsin inhibitor heavy chain H7,Inter-alpha-trypsin inhibitor heavy chain H5,Inter-alpha-trypsin inhibitor heavy chain H4,Inter-alpha-trypsin inhibitor heavy chain H4 |
UniprotKB Entry Name | ITIH4_HUMAN,ITIH4_HUMAN,ITIH4_HUMAN,ITIH4_HUMAN |
Fluid | Serum,Serum,Serum,Serum |
M/Z | 1786.86,1786.86,1785.84747,1785.85 |
Charge | 1,1,1,1 |
Mass (in Da) | 1786.85,NA,NA,1787.97 |
fdr | NA,NA,NA,NA |
Profiling Technique | MALDI-TOF,MALDI-TOF,LC-MS,MALDI-TOF |
Peptide Identification technique | Q/TOF MS/MS,Q/TOF/TOF and LC-MS/MS,LC-MS-MS/MS,FT-ICR MS/MS + nano-HPLC |
Quantification Technique | NA,NA,LC-ESI-MS,NA |
Labelled/Label Free | Label Free,Label Free,Label Free,Label Free |
FDR | NA,less than 1 “5,NA,NA |
CancerPDF_ID | CancerPDF_ID49, CancerPDF_ID1060, CancerPDF_ID1862, CancerPDF_ID8570, |
p-Value | 1.00E-05,less than 0.01,NA,NA |
Software | MASCOT,MASCOT (v 2.0.04 for Windows),MASCOT(v. 2.2.01),MASCOT |
Length | 17,17,17,17 |
Cancer Type | Metastatic thyroid carcinomas,"Advanced Prostate, Breast and Bladder cancer",Colorectal cancer,"Breast cancer, Lung cancer, Rectal cancer" |
Database | NCBI refseq Protein Database,NCBI refseq Protein Database,SwissProt Database,NA |
Modification | NA,NA,NA,NA |
Number of Patients | 40 metastatic thyroid carcinoma patients and 40 normal for training phase and 10 metastatic thyroid carcinoma and 10 normal individuals for independent validation,"Advanced prostate (n = 32), breast (n = 21), and bladder (n = 20) cancer, 33 healthy in training test set, In validation set 41 independent serum samples from patients with advanced prostate cancer (prostate 2 [PR2])",30 patients and 30 healthy controls,"Breast Cancer =84, lung cancer= 70, Rectal cancer = 30patients; 500 healthy" |
Regulation | NA,"Upregulated in cancer vs normal with Ratio of median intensity (patients/Controls) =2.39, 2.88 and 2.3 in prostate, bladder and breast cancer respectively",NA,NA |
Validation | Independent validation,Independent validation,Leave One out Cross validation,NA |
Sensitivity | 95% on independent dataset,97.5% on independent validation dataset,NA,NA |
Specificity | 95% on independent dataset,NA,NA,NA |
Accuracy | NA,97.5 % on validation dataset,NA,NA |
Peptide Atlas | PeptideAtlas |
IEDB | |