Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1647

PRIMARY INFORMATION
ID1647
PMID8321834
Year1992
SequenceCGNLSTCMLGTYTQ
DFNKFHTFPQTAIGVGAP
Namethyrocalcitonin
Length32
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic human calcitonin
Nature of Peptide/CargoNot mentioned
MechanismNot mentioned
Cargo Sequence/StructureNo cargo
Name of cargo
Not applicable
Assaypermeability coefficient for transdermal iontophoretic transport of peptide/ protein drugs from p-HEMA hydrogels was measured.
EnhancerPH 3.6
Properties of enhancerNot mentioned
Concentration0.65 uM
Incubation time36 hrs
Tissue permeability (value with units)1.95(cm/sec) * 10 8
Tissue Sampleskin of hairless rat
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N
[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C=O)
CCC)C)C(C)C)[C@H](CC)C)C)[C@H]
(O)C)CCC(=O)N)CCC2)Cc2ccccc2)[C@H](O)C)C
c2[nH]cnc2)Cc2ccccc2)CCCCN)CC(=O)N)Cc2ccccc2)
CC(=O)O)CCC(=O)N)[C@H](O)C)Cc2ccc(cc2)O)
[C@H](O)C)CC(C)C)CCSC)CSSC1)[C@H](O)
C)CO)CC(C)C)CC(=O)N