| ID | 1603 | |
| PMID | 25499919 | |
| Year | 2015 | |
| Sequence | RRRRRRR | |
| Name | Poly arginine(Poly-R) | |
| Length | 7 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic | |
| Nature of Peptide/Cargo | Not mentioned | |
| Mechanism | Not mentioned | |
| Cargo Sequence/Structure | CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | |
| Name of cargo | Cyclosporine A (CsA) | |
| Assay | Tape-Stripping, Franz diffusion cells | |
| Enhancer | Ethanol/PBS,pH 7.4 | |
| Properties of enhancer | Not mentioned | |
| Concentration | 25mg/ml | |
| Incubation time | 24hrs | |
| Tissue permeability (value with units) | More than 25% of the applied CsA penetrated the skin. | |
| Tissue Sample | Porcine skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC (=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H] (CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O) N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC (=[NH2])N)C=O | |