Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1586

PRIMARY INFORMATION
ID1586
PMID24637683
Year2014
SequenceKFFKKLKNSVKKRAK
KFFKKPRVIGVSIPF
NameOH-CATH30
Length30
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideNaturally occurs in King Cobra
Nature of Peptide/CargoCationic peptide of cathelicidin family. Exerts potent antibacterial activity, selective immunomodulatory properties and low toxicity to eukaryotic cells
MechanismNaturally occurs in King Cobra
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayTime kill assay, Clinical and histological examination, Measurement of bacterial burden
EnhancerP.aeruginosa 447 was used to induce bacterial keratitis
Properties of enhancerNot mentioned
Concentration20 µl drop of 1 mg/ml concentration of peptide and 20 µl drop of 1 mg/ml concentration of Levofloxacin
Incubation time1 hour
Tissue permeability (value with units)Bacterial burden: OH-CATH30- 5.7 Log10 CFU/cornea; PBS- 8.1 Log10 CFU/cornea; Levofloxacin- 6.1 Log10 CFU/cornea; Peptide+Levofloxacin- 3.9 Log10 CFU/cornea
Tissue SampleCornea
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)
N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C=O)
Cc3ccccc3)CCC2)[C@H](CC)C)CO)C(C)C)[C@H](CC)C)C(C)C)
CCCNC(=N)N)CCC1)CCCCN)CCCCN)Cc1ccccc1)Cc1ccccc1)
CCCCN)CCCCN)C)CCCNC(=N)N)CCCCN)CCCCN)C(C)C)
CO)CC(=O)N)CCCCN)CC(C)C)CCCCN)CCCCN)Cc1ccccc1)
Cc1ccccc1)CCCCN