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Details of TopicalPdb ID 1484

PRIMARY INFORMATION
ID1484
PMID3503119
Year1986
SequenceYaGFM
Name[D-ala2]-met-enkephalinamide
Length5
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityMix
Chemical ModificationNone
Origin of PeptideType of enkephalin
Nature of Peptide/CargoA potent opioid peptide
MechanismType of enkephalin
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioactive determination
Enhancer0.5 ml of ice-cold 0.3N perchloric acid
Properties of enhancerNot mentioned
Concentration25µl of 50µM peptide
Incubation time10 minutes
Tissue permeability (value with units)Tissue: Corneal epithelium- intact peptide=30pmoles/g tissue, degraded peptide=75pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=19.2%
Tissue SampleSuperior limbus of both eyes of each male, albino New Zealand rabbits
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]
(C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C
(=O)N[C@@H](CCSC)C(=O)N