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Details of TopicalPdb ID 1452

PRIMARY INFORMATION
ID1452
PMID3503119
Year1986
SequenceYGGFL
NameLeucine enkephalin
Length5
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideType of enkephalin
Nature of Peptide/CargoLeu-enkephalin is an endogenous opioid peptide neurotransmitter that is found naturally in the brains of many animals, including humans.
MechanismType of enkephalin
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioactive determination
Enhancer0.5 ml of ice-cold 0.3N perchloric acid
Properties of enhancerNot mentioned
Concentration25µl of 50µM peptide
Incubation time5 minutes
Tissue permeability (value with units)Tissue: Corneal stroma- intact peptide=28pmoles/g tissue, degraded peptide=31pmoles/g tissue, Percent of recovered enkephalin attributable to degradation products=87.9%
Tissue SampleSuperior limbus of both eyes of each male, albino New Zealand rabbits
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccc(O)cc1)C(=O)NCC
(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)
N[C@@H](CC(C)C)C=O