| PRIMARY INFORMATION |
|---|
| ID | 1403 |
| PMID | 1144451 |
| Year | 1975 |
| Sequence | (Chain A: GIVEQCCTSICSLYQLENYCN)
(Chain B: FVNQHLCGSHLVEALYLVCGERGFFYTPKT) |
| Name | Insulin |
| Length | 51 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Cyclic (Chain A: C6-C11)(Chain A:C7-Chain B:C7) (Chain A:C20-Chain B:C19) |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | Synthetic (USP Lilly Iletin 80 U/cc) |
| Nature of Peptide/Cargo | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| Mechanism | Synthetic (USP Lilly Iletin 80 U/cc) |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Chloride in the sweat determined by titration with a Cotiove chloridometer |
| Enhancer | Pilocarpine iontophoresis |
| Properties of enhancer | Not mentioned |
| Concentration | 80 U/cc |
| Incubation time | 10 minutes iontophoresis followed by 30 minutes collection |
| Tissue permeability (value with units) | Control/Cystic fibrosis patients: 14.81±2.39/16.03±2.34(Vehicle treated) and 14.47±2.66/11.52±1.28(Insulin treated) |
| Tissue Sample | Stratum corneum of arm of cystic fibrosis patients |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
