Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1373

PRIMARY INFORMATION
ID1373
PMID21297299
Year2011
SequenceFCIGRLCG
NameAT 1002 analog
Length8
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideAnalogue of AT 1002
Nature of Peptide/CargoCell penetrating peptide
MechanismNot mentioned
Cargo Sequence/StructureSense- 5' AUC CGC GCG AUA GUA CGU ATT 3' Antisense- 5' 6-FAM UAC GUA CUA UCG CGC GGA UTT 3'
Name of cargo
FAM-labeled siRNA
AssayConfocal laser microscopy
EnhancerSkin was shaved
Properties of enhancerHairless skin eases transdermal delivery
Concentration5 µg siRNA+ 400 µg peptide
Incubation time10 hours
Tissue permeability (value with units)Fluorescent signals of FAMsiRNA in the AT1002 applied skin were observed faintly at the stratum corneum in 10 times tape-stripped skin. In 20 times tape-stripped skin FAMsiRNA was observed widely and strikingly at the stratum corneum, hair follicle, epidermal and dermal layers.
Tissue SampleTape stripped skin of female ICR mice
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)
N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)NCC=O