| PRIMARY INFORMATION |
|---|
| ID | 1345 |
| PMID | 1977237 |
| Year | 1990 |
| Sequence | pGlu-EDSG |
| Name | Epidermal pentapeptide |
| Length | 5 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Hydroxylation |
| Linear/ Cyclic | Linear |
| Chirality | L |
| Chemical Modification | pGlu= Pyroglutamic acid |
| Origin of Peptide | Synthetic |
| Nature of Peptide/Cargo | It induces a moderate but long-lasting inhibition of epidermal cell proliferation when given at low (picomol) doses but stimulates epidermal cell proliferation at higher doses |
| Mechanism | It induces long-lasting oscillations in the epidermal mitotic rate and DNA synthesis. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Colcemid-arrested mitoses and labelled cells were counted per 12 mm of interfollicular epidermis in 5 pm paraffin sections stationed with haematoxylin in the former and dipcoated with NTB 2 emulsion and incubated for 3 weeks at 0-4 ͦC for later. The statistical evaluations were made according to the Wilcoxon's rank sum test. |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 0.004% (wt/wt) EPP cream |
| Incubation time | 30 minutes |
| Tissue permeability (value with units) | Significant mitotic rate inhibition initially and on day 7 after an overshoot on day 6 |
| Tissue Sample | Back skin of female hairless mice (hr/hr) |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
