Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1339

PRIMARY INFORMATION
ID1339
PMID2054872
Year1991
SequenceSNLST-Asu-VLGKLSQEL
HKLQTYPRTDVGAGTP
NameElcatonin
Length31
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicCyclic (bond between Ser1 and Asu6)
ChiralityL
Chemical ModificationAsu=Aminosuberic Acid
Origin of PeptideSynthetic analogue of eel calcitonin in which disulfide bridge between first and seventh amino acids is replaced by -CH2CH2- bridge
Nature of Peptide/CargoIt stimulates osteoblastic bone formation in addition to inhibiting osteoclastic bone resorption
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
Assayo-cresolphthalein complexone method using Calcium C-Test Wako and 0.01 ml plasma, pharmacokinetic and statistical analysis
Enhancern-octyl-β-D-thioglucoside=1.5g, Taurocholate=1g
Properties of enhancerNot mentioned
ConcentrationCarbopol 934-2.0g, Elcatonin-25.0mg, Propylene glycol-10.0g, Gentamycin sol.-2.0g, Purified water ad.-100.0g and enhancers
Incubation time24 Hours
Tissue permeability (value with units)Area under the curve(mg.h/dl)=53.50±14.96 , Area under the first moment curve(mg.h2/dl)=752.04±298.40 , The mean residence time(h)=13.66±3.46 , Apparent bioavailability(%)=4.62.
Tissue SampleStratum corneum of the abdominal area of male Wistar rats(0.5g ointment/4 cm2/rat)
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.