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Details of TopicalPdb ID 1323

PRIMARY INFORMATION
ID1323
PMID2433236
Year1986
SequenceA-isoGln-A
NameMuramyl tripeptide-phosphatidylethanolamine (MTP-PE, CGP 19835)
Length3
N-Terminal ModificationmuramylNAc=Muramyl-N-Acetyl
C-Terminal ModificationPE=phosphatidylethanolamine
Linear/ CyclicLinear
ChiralityL
Chemical ModificationisoGln=Isoglutamine
Origin of PeptideA lipophilic derivative of N-acetyl-muramyl-L-alanyl-D-isoglutisoglutamine (MDP)
Nature of Peptide/CargoMTP-PE is a stimulator of innate immunity and a synthetic molecule derived from muramyl dipeptide (MDP). MTP-PE results from the covalent addition of alanin and dipalmitoyl phosphatidyl ethanolamine to MDP , which is a peptidoglycan found in Gram-positive and Gram-negative bacterial cell walls.
MechanismImmunomodulators, which are able to modify the host's specific or non-specific defence mechanisms.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayPlaque reduction assay using calf kidney cells
EnhancerHerpes simplex 2/Alabama viral inoculum logPFU (route)=3 (i.vag.), Minimum effective dose level=0.1 mg/kg
Properties of enhancerNot mentioned
Concentration10 mg/ml sterile MTP-PE incorporated into a gel consisting of 20 g CMC/I dist. water (nine parts) and glycerol (one part).
Incubation timeMTP-PE was administered 7 days before infection
Tissue permeability (value with units)Initial symptomatology to Herpes simplex 2/Alabama is milder, the local disease is significantly mitigated by MTP-PE (P≤ 0.05). Recovery is accelerated and animal becomes asymptomatic by day 15-20.
Tissue SampleTif:DHP Dunking-Hartley Pirbright guinea pigs. After slight abrasion of the vaginal mucosa, a piece of fibrin foam impregnated with virus suspension was introduced into the vagina.
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.