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Details of TopicalPdb ID 1321

PRIMARY INFORMATION
ID1321
PMID2533571
Year1989
SequenceTSEKSQTPLVTL
Namedes-enkephalin-ƴ-endorphin(DEƴE)
Length12
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoA highly potent neuropeptide which has been implicated in schizophrenic psychoses
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioactive assay
EnhancerAzone
Properties of enhancerPenetration enhancer
ConcentrationPeptide concentration in the donor: 0.9*104M
Incubation timeThe acceptor consisting of PBS (pH 7.4) was pumped through at a flow rate of 5 ml/h and collected at hourly intervals in a fraction collector.
Tissue permeability (value with units)Permeability coefficient:4.7*105 cm/hour, flux of radiolabelled material:4.2*1012 mol/hour/cm2
Tissue SampleHuman stratum corneum
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C
(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)
C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C=O