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Details of TopicalPdb ID 1314

PRIMARY INFORMATION
ID1314
PMID2845208
Year1988
SequenceSYS-Nle-EHfRWGKPV
Name[Nle4, D-Phe7]-alpha-MSH
Length13
N-Terminal ModificationAcetylation
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityMix
Chemical ModificationNle=Norleucine
Origin of PeptideDerived from α-MSH
Nature of Peptide/CargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes.
MechanismTopically applied melanotropin could activate cellular processes within follicular melanocytes leading to new eumelanin formation
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioimmunoassay
EnhancerEach skin sample was sectioned, stained with hematoxylin and eosin and examined by light microscopy
Properties of enhancerNot mentioned
ConcentrationFirst dissolved at 10-3M in distilled water and then diluted in a polyethylene glycol vehicle (26% PEG 400 and 74% PEG 3350, by weight) to 10-4M
Incubation time24 hours
Tissue permeability (value with units)Percent positive samples of transdermal delivery :11.8% (2/17)
Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats.
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)
C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](Cc1nc[nH]c1)C
(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)
N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCC[NH3])
C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N