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Details of TopicalPdb ID 1241

PRIMARY INFORMATION
ID1241
PMID11179600
Year2001
SequencepGlu-3-methyl-HP
NameM-TRH
Length3
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationpGlu= Pyroglutamic acid, 3-methyl-H=3-methyl-histidine
Origin of PeptideAnalogue of TRH
Nature of Peptide/CargoTRH has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders besides its well known endocrinological effects
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayCardiovascular parameters and blood gas values determined by collecting blood at different time intervals
Enhancer3% cineole and 47% ethanol in PBS
Properties of enhancerIncreases effective penetration of peptide
ConcentrationInitially 100µl of 5 mg/ml of peptide was applied followed by continuous renewal by 50µl/h.
Incubation time0 Minutes
Tissue permeability (value with units)On application of M-TRH, cardiovascular parameters and blood gas values:Mean arterial blood pressure(kPa)-11.0 ± 0.31, Basal skin blood flow(PU)-382 ± 32, Heart rate(min-1)-400 ± 8, Respiratory rate(min-1)-116 ± 7, pH-7.35 ± 0.01, pCO2(pKa)-7.73 ± 0.24 and pO2(pKa)-9.59 ± 1.04
Tissue SampleStratum corneum of the abdominal area of male Sprague-Dawley rats
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.