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Details of TopicalPdb ID 1193

PRIMARY INFORMATION
ID1193
PMID15734548
Year2005
SequenceCGSGVRGDFGSLAPR
VARQL
NamePeptide 141–159 from the VP1 protein of serotype A12
Length20
N-Terminal ModificationConjugated to BSA
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic peptide representing residues 141–159 from the GH loop of VP1 protein of foot-and-mouth disease virus
Nature of Peptide/CargoElicits virus neutralising antibodies in mice after transcutaneous immunisation
MechanismNot mentioned
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayNeutralisation assay
EnhancerPeptide conjugated to BSA together with Cholera toxin
Properties of enhancerElicited anti-peptide antibody responses with strong virus neutralising activity
Concentration30 µl of 100 µg 141–159 peptide conjugated to BSA together with 100 µg Cholera Toxin
Incubation timeBooster applications with the same dose and formulation were given on days 21, 42, and 63.
Tissue permeability (value with units)Neutralisation indices of anti-peptide antibody responses=2.7 after third booster
Tissue SampleAbdominal skin of BALB/c mice
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C(C)C)C
(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)
C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)
N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](C(C)C)C(=O)
N[C@@H](C)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C=O