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Details of TopicalPdb ID 1093

PRIMARY INFORMATION
ID1093
PMID22072881
Year2011
SequenceRKKRRQRRR
NameTat
Length9
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideHIV-1
Nature of Peptide/CargoFor promoting the skin penetration of molecules
MechanismNot mentioned
Cargo Sequence/StructureLipophilic nature
Name of cargo
Hirsutenone (HST)
AssayFranz diffusion cells, HPLC
EnhancerConventional cream
Properties of enhancerNot applicable
ConcentrationNot mentioned
Incubation time24 hour
Tissue permeability (value with units)Permeation parameters observed were5.74 ± 1.32%
Tissue SampleDorsal skin of mice
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C(=O)N
[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])N)
C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC
(=[NH2])N)C(=O)N[C@@H](CCCNC(=[NH2])
N)C(=O)N[C@@H](CCCNC(=[NH2])N)C=O