| ID | 1020 | |
| PMID | 23391375 | |
| Year | 2013 | |
| Sequence | ACSSSPSKHCG | |
| Name | TDN | |
| Length | 11 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Amidation | |
| Linear/ Cyclic | Cyclic (C2-C10) | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Synthetic cationic cyclopeptides | |
| Nature of Peptide/Cargo | TD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | |
| Mechanism | It creates a transient opening in the skin barrier to enable macromolecular drugs to reach systemic circulation | |
| Cargo Sequence/Structure | Not mentioned | |
| Name of cargo | Rhodamine-insulin | |
| Assay | Confocal Laser Scanning Microscopy | |
| Enhancer | None | |
| Properties of enhancer | Not applicable | |
| Concentration | 0.014 μmol of rhodamine-insulin and 0.5 μmol of TDN, 100 μL of saline | |
| Incubation time | 8 hours | |
| Tissue permeability (value with units) | Significant permeability of the peptide can be seen in confocal images | |
| Tissue Sample | Male SD rats skin cells | |
| Ex vivo/In vivo/In vitro | ex vivo | |
| STRUCTURE |
| |
| SMILES | N[C@@H](C)C(=O)N[C@H]1CSSC[C@H](NC(=O) [C@@H](NC(=O)[C@@H](NC(=O)[C@@H] (NC(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](NC (=O)[C@@H](NC1=O)CO)CO)CO)CCC2)CO)CCCC [NH3])Cc1nc[nH]c1)C(=O)NCC(=O)N | |