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The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1495 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Radioimmunoassay | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:55±125ng/ml, Aqueous humor:168±184 and Cornea:432±150ng/ml | Eyes of New Zealand white rabbits | 3977661 |
| 1496 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Radioimmunoassay | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:68±100ng/ml, Aqueous humor:46±27 and Cornea:762±330ng/ml | Eyes of New Zealand white rabbits | 3977661 |
| 1497 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Radioimmunoassay | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:87±153ng/ml, Aqueous humor:68±49 and Cornea:926±384ng/ml | Eyes of New Zealand white rabbits | 3977661 |
| 1498 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Radioimmunoassay | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:75±75ng/ml, Aqueous humor:62±35 and Cornea:557±194ng/ml | Eyes of New Zealand white rabbits | 3977661 |
| 1499 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Radioimmunoassay | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Cornea:584±90ng/ml | Eyes of New Zealand white rabbits | 3977661 |
| 1500 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Radioimmunoassay | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:0±19ng/ml, Aqueous humor:24±12and Cornea:672±275ng/ml | Eyes of New Zealand white rabbits | 3977661 |
| 1502 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | Secretoneurin (SN) is detected in 10-100µl of aqueous humor, aspirated immediately before surgery by radioimmunoassay | Secretoneurin-like immunoreactivities were detectable and averaged 474.24 fmol/ml (±34.4) in the Cy A group. | Human patients(8 eyes) undergoing cataract surgery belonging to 39-91 years of age | 15572199 |
| 1517 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse cubic phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | Franz diffusion cell, HPLC | Amount of applied dose/cm2 present in stratum corneum=1.8%, 1.0%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=0.3%, 0.35%(Control) | In-vitro model of porcine ear skin | 16621488 |
| 1518 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse cubic phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | Franz diffusion cell, HPLC | Amount of applied dose/cm2 present in stratum corneum=2.9%, 1.3%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=0.41%, 0.38%(Control) | In-vitro model of porcine ear skin | 16621488 |
| 1519 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse cubic phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | Franz diffusion cell, HPLC | Amount of applied dose/cm2 present in stratum corneum=7.0%, 1.9%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.2%, 0.7%(Control) | In-vitro model of porcine ear skin | 16621488 |
| 1520 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse hexagonal phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | Franz diffusion cell, HPLC | Amount of applied dose/cm2 present in stratum corneum=0.9%, 1%(Control) | In-vitro model of porcine ear skin | 16621488 |
| 1521 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse hexagonal phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | Franz diffusion cell, HPLC | Amount of applied dose/cm2 present in stratum corneum=1.5%, 1.3%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.1%, 0.38%(Control) | In-vitro model of porcine ear skin | 16621488 |
| 1522 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse hexagonal phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | Franz diffusion cell, HPLC | Amount of applied dose/cm2 present in stratum corneum=2.0%, 1.9%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.5%, 0.7%(Control) | In-vitro model of porcine ear skin | 16621488 |
| 1523 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse cubic phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | HPLC | Amount of applied dose/cm2 present in stratum corneum=2.75%, 1.1±0.13%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.1%, 0.61±0.09%(Control) | Skin(Stratum corneum and Epidermis without stratum corneum + dermis) of hairless mice | 16621488 |
| 1524 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A (CysA) bearing reverse hexagonal phase | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | HPLC | Amount of applied dose/cm2 present in stratum corneum=1.89%, 1.1±0.13%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.6%, 0.61±0.09%(Control) | Skin(Stratum corneum and Epidermis without stratum corneum + dermis) of hairless mice | 16621488 |
| 1605 | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporin A | Not mentioned | Franz 2-type vertical diffusion model. | Skin permiation efficiency of CsA-loaded SLN was 2 fold higher than that of CsA-oil mixture in viable skin. | Murine skin | 19746839 |
| 1657 | Aa-MeLeu-MeLeu-MeVal- 3-hydroxy-N,4-dimethyl-L-2-amino- 6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | Cyclosporine | Not mentioned | Dual-color fluorescence microscopy. | The inflammation was healed in the treated ear. | mouse and human skin | 11062537 |