NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Silymarin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
APAF1apoptotic peptidase activating factor 1317preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the protein Apaf-1.15713892
BAXBCL2-associated X protein581preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the proteins of Bcl-2 family.15713892
BCL2B-cell CLL/lymphoma 2596preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the proteins of Bcl-2 family.15713892
BCL2L1BCL2-like 1598preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the proteins of Bcl-2 family.15713892
CASP3caspase 3, apoptosis-related cysteine peptidase836preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the activation of caspase-3.15713892
CYCScytochrome c54205preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the protein cytochrome c.15713892
PARP1poly (ADP-ribose) polymerase 1142preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role. p53-dependent pathway involves the activation of PARP.15713892
TP53tumor protein p537157preneoplastic epidermal keratinocytesJB6 C141----Silymarin-induced apoptosis in JB6 C141 cells primarily mediated through a p53-dependent pathway, and p53-independent pathway seems to have a minor role.15713892

 






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