NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Piroxicam

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
APAF1apoptotic peptidase activating factor 1317Colon Cancer1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley rats----Results confirmed that DMH treatment for 6wk led to a significant decline in the protein expression of Apaf-1 in the rat colonic mucosa in comparison to control22369161
APAF1apoptotic peptidase activating factor 1317Colon carcinogenesis-----Results confirmed that DMH treatment for 6wk led to a significant decline in the protein expression of Apaf-1 in the rat colonic mucosa in comparison to control22369161
BAXBCL2-associated X protein581Colon Cancer1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley rats----The expression of the proapoptotic protein, Bax was shown to be considerably elevated on piroxicam treatment.22369161
BAXBCL2-associated X protein581Colon carcinogenesis-----The expression of the proapoptotic protein, Bax was shown to be considerably elevated on piroxicam treatment.22369161
BCL2B-cell CLL/lymphoma 2596Colon Cancer1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley rats----Results illustrated that piroxicam treatment stimulate cytochrome c release by downregulating the Bcl-2 (an antiapoptotic protein) expression significantly22369161
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon Cancer1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley rats----Results illustrated that piroxicam treatment activated the caspase activity22369161
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon Cancer1,2-Dimethylhydrazine Dihydrochloride Induced Colon Carcinogenesis in Male Sprague-Dawley rats----Results illustrated that piroxicam treatment activated the caspase activity22369161

 






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