NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Piceatannol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCNB1cyclin B1891Colon cancerHCT-116----G2/M regulating cyclin B1 was expressed at lower levels.11823594
CCNB1cyclin B1891Colorectal AdenocarcinomaCaCo-2----G2/M regulating cyclin B1 was expressed at lower levels.11823594
CCND1cyclin D1595Colon cancerHCT-116----G0/G1 phase-regulating proteins,cyclin D1, was expressed at lower levels.11823594
CCND1cyclin D1595Colorectal AdenocarcinomaCaCo-2----G0/G1 phase-regulating proteins,cyclin D1, was expressed at lower levels.11823594
CCNE1cyclin E1898Colon cancerHCT-116----Cyclin E protein expression of HCT-116 cells was enhanced.11823594
CCNE1cyclin E1898Colorectal AdenocarcinomaCaCo-2----Treated Caco-2 cells progress over this restriction point with elevated cyclin E protein levels, which could account for the observed downregulation of p27KIP1.11823594
CDK4cyclin-dependent kinase 41019Colon cancerHCT-116----G0/G1 phase-regulating proteins cdk4 was expressed at lower levels.11823594
CDK4cyclin-dependent kinase 41019Colorectal AdenocarcinomaCaCo-2----G0/G1 phase-regulating proteins cdk4 was expressed at lower levels.11823594
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Colon cancerHCT-116----p27KIP1 levels were diminished in cell lines tested.11823594
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)1027Colorectal AdenocarcinomaCaCo-2----p27KIP1 levels were diminished in cell lines tested.11823594
CycACyclin A39340Colorectal AdenocarcinomaCaCo-2----Piceatannol treatment led to a dose-dependent increase in cyclin E levels and an elevation of cyclin A levels.11823594
CycACyclin A39340Colon cancerHCT-116----The expression level of Cyclin A was diminished with the treatment of piceatannol.11823594

 






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