NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Neorautenol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP3caspase 3, apoptosis-related cysteine peptidase836Murine Hepatocellular carcinomaH4-II-E-1µM --Neorautenol increased caspase-3 activity and nuclear fragmentation as markers for apoptotic cell death. 17964704
CASP7caspase 7, apoptosis-related cysteine peptidase840Murine Hepatocellular carcinomaH4-II-E-1µM --Neorautenol increased caspase-7 activity and nuclear fragmentation as markers for apoptotic cell death. 17964704
MAPK1mitogen-activated protein kinase 15594Murine Hepatocellular carcinomaH4-II-E-1µM --Neorautenol (10µM, 2 h) decreased the activation of the ERK kinase (p44/p42), an mitogen activated protein kinase which is associated with cell proliferation.17964704

 






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