NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Inuviscolide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
birc5abaculoviral IAP repeat-containing 5a373110MelanomaSK-28----The anti-apoptotic proteins, p65 subunit of nuclear factor kB (NF-kappaB), and Survivin were reduced in a dose-dependentmanner.17919456
CCNB1cyclin B1891MelanomaSK-28----Rapid inhibitory phosphorylation of Cdc2 (Thr14 and Tyr15) was seen early after treatment, followed by a later decrease in the expression level of Cyclin B1.17919456
CDK1cyclin-dependent kinase 1983MelanomaSK-28----Rapid inhibitory phosphorylation of Cdc2 (Thr14 and Tyr15) was seen early after treatment, followed by a later decrease in the expression level of both Cyclin b1 and Cdc2.17919456
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026MelanomaSK-28----Rapid inhibitory phosphorylation of Cdc2 (Thr14 and Tyr15) was seen early after treatment, followed by a later decrease in the expression level of both Cyclin b1 and Cdc2. Induction of p53 and p21wafi proteins and phosphorylation of p53 at Ser15 were also detected early after treatment.17919456
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790MelanomaSK-28----The anti-apoptotic proteins, p65 subunit of nuclear factor kB (NF-kappaB), and Survivin were reduced in a dose-dependentmanner.17919456
TP53tumor protein p537157MelanomaSK-28----Rapid inhibitory phosphorylation of Cdc2 (Thr14 and Tyr15) was seen early after treatment, followed by a later decrease in the expression level of both Cyclin b1 and Cdc2. Induction of p53 and p21wafi proteins and phosphorylation of p53 at Ser15 were also detected early after treatment.17919456

 






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