NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Indole-3-carbinol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PARP1poly (ADP-ribose) polymerase 1142Prostate CancerPC-3----The induction of apoptosis was pronounced at 48 h of treatment, and appears to be correlated with cell growth inhibition. In addition , PARP cleavage analys is showed that the full size PARP (116 KD) protein was cleaved to yield an 85 kD a fragment after treatment with Indole-3-carbinol (I3C) for 48 h in PC-3 cells providing further evidence for the induction of apoptosis in I3C treated PC-3 cells.11420705

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.