NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Helenalin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CASP8caspase 8, apoptosis-related cysteine peptidase841Human leukemia Jurkat T J16----Helenalin led to activation of caspase-8.11479221
CYCScytochrome c54205Human leukemia Jurkat T J16----Helenalin, indeed, initiated redistribution of cytochrome c into the cytosol as early as 8 h after cell treatment. Thus, cytochrome c release seemed to be an early event in the helenalin-mediated apoptosis that preceded caspase-3-like activity.11479221
FASLGFas ligand (TNF superfamily, member 6)356Human leukemia Jurkat T J16----Examining CD95-L expression, no up-regulation could be detected over a period of 24 h. In contrast, helenalin treatment decreased CD95-L expression.11479221

 






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