NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Diallyldisulfide

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Breast CarcinomaMDA-MB-2311.8 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in all four cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BAXBCL2-associated X protein581Breast CancerKPL-111.9 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BAXBCL2-associated X protein581Breast CancerMKL-F18.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BAXBCL2-associated X protein581Breast adenocarcinomaMCF-74.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised up-regulation of Bax protein (142%).11375895
BCL2L1BCL2-like 1598Breast CancerMKL-F18.1 µM (72h)---In an in vitro MTT assay, DADS at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in all four cell lines examined;the apoptosis cascade comprised down-regulation of Bcl-XL protein (38%).11375895
BCL2L1BCL2-like 1598Breast CarcinomaMDA-MB-2311.8 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised down-regulation of Bcl-XL protein (38%).11375895
BCL2L1BCL2-like 1598Breast CancerKPL-111.9 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised down-regulation of Bcl-XL protein (38%).11375895
BCL2L1BCL2-like 1598Breast adenocarcinomaMCF-74.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised down-regulation of Bcl-XL protein (38%).11375895
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CarcinomaMDA-MB-2311.8 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).11375895
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CancerKPL-111.9 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).11375895
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast CancerMKL-F18.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).11375895
CASP3caspase 3, apoptosis-related cysteine peptidase836Breast adenocarcinomaMCF-74.1 µM (72h)---In an in vitro MTT assay, Diallyldisulfide at an IC50 of 1.8 -18.µM after 72 h incubation caused inhibition of growth in cancer cell lines examined;the apoptosis cascade comprised activation of caspase-3 (438%).11375895

 






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