NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cycleanine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
Dox--Breast adenocarcinomaMCF7/Ad (P-gp positive)----MDR was modulated by Cycleanine, due to the increase of intracellular Dox accumulation; significantly enhanced the cytotoxic effect of Dox or VCR to P-gp positive MCF-7/Adr cell in a dose-dependant manner, but not to their parental sensitive MCF-7 cells and KB cells, which do not overexpress P-gp, and caused the increased intracellular Dox accumulaion in MCF-7/Adr cells, but not in their parental sensitive MCF-7 cells.10322941

 






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