NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Cepharanthine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
AKT1v-akt murine thymoma viral oncogene homolog 1207Liver CancerHUH7----Cepharanthine(CEP) triggered the generation of reactive oxygen intermediates,the activation of mitogen activated the downregulation of protein kinase B/Akt.16412424
CASP3caspase 3, apoptosis-related cysteine peptidase836Liver CancerHUH7----Cepharanthine(CEP) stimulated a 4.2 ± 0.3-fold increase in caspase-3-like activities at 12 h and the treatment of HuH-7 cells with a specific and potent inhibitor of caspase-3 significantly blocked CEP-induced apoptotic cell death (cells viability in-creased to 82 ± 8% in the presence of 10lM caspase-3 inhibitor), thus indicating the CEP-induced cell death followed by caspase-3 activation.16412424
CYCScytochrome c54205Liver CancerHUH7----After a 2-h exposure of Cepharanthine, cytochrome c was detectable and it significantly increased at 4 h in the cytoplasmic protein fraction16412424
MAPK1mitogen-activated protein kinase 15594Liver CancerHUH7----Cepharanthine(CEP) triggered the generation of reactive oxygen intermediates,the activation (MAPK) p38, 16412424
MAPK3mitogen-activated protein kinase 35595Liver CancerHUH7----Cepharanthine(CEP) triggered the generation of reactive oxygen intermediates,the activation p44/4216412424
MAPK8mitogen-activated protein kinase 85599Liver CancerHUH7----Cepharanthine(CEP) triggered the generation of reactive oxygen intermediates,the activation of JNK1/2 16412424
PARP1poly (ADP-ribose) polymerase 1142Liver CancerHUH7----Cepharanthine(CEP) treatment markedly induced PARP cleavage, thus suggesting that mitochondrial events were also associated with the CEP-induced hepatoma cell death process.16412424

 






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