NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Capsaicin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ARandrogen receptor367Prostate CancerLNCaP----Capsaicin profoundly inhibited protein levels of AR.The reporter gene studies showed that capsaicin inhibited androgen activation of the AREs in the PSA regulatory region. Furthermore, reporter gene experiments revealed that even when AR was exogenously overexpressed in LNCaP cells.16540674
BAXBCL2-associated X protein581Prostate CancerLNCaP----In the wild-type p53 expressing LNCaP cells, capsaicin induced Bax expression in a time-dependent manner.16540674
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1026Prostate CancerLNCaP----In the wild-type p53 expressing LNCaP cells, capsaicin induced p21 expression in a time-dependent manner.16540674
KLK3kallikrein-related peptidase 3354Prostate CancerLNCaP----Capsaicin profoundly inhibited protein levels of PSA. The reporter gene studies showed that capsaicin inhibited androgen activation of the AREs in the PSA regulatory region.16540674
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Prostate CancerPC-3----The NF-kappaB transcriptional activity is constitutively robust in PC-3 cells as shown by their stimulation of a reporter gene containing NF-kappaB binding sites. However, this activity of NF-kappaB was dramatically inhibited by capsaicin.16540674
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 4792Prostate CancerPC-3----Capsaicin inhibited the TNF-alpha-induced IkBalpha degradation in the cytoplasm, thus preventing the TNF-alpha-dependent translocation of NF-kappaB to the nucleus. Furthermore, IkBalpha protein levels increased in PC-3 cells; capsaicin either stabilizes the IkBalpha and/or inhibits the IKK activity, resulting in the inhibition of IkBalpha degradation. 16540674
TP53tumor protein p537157Prostate CancerLNCaP----In the wild-type p53 expressing LNCaP cells, capsaicin induced p53 expression in a time-dependent manner.16540674

 






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