NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Antofine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BCL2B-cell CLL/lymphoma 2596Colon cancerHCT-116----Stimulation with TNF-alpha also markedly increased the expression of Bcl-2 and Bcl-XL.20674553
BCL2L1BCL2-like 1598Colon cancerHCT-116----Stimulation with TNF-alpha also markedly increased the expression of Bcl-2 and Bcl-XL.20674553
CASP8caspase 8, apoptosis-related cysteine peptidase841Colon cancerHCT-116----Antofine or TNF-alpha alone showed marginal effects on the cleavage of caspase-8.20674553
CCND1cyclin D1595Colon cancerHCT-116----The expression level of beta-catenin and one of its transcriptional targets, cyclin D1, were suppressed by Antofine in HCT 116 cells.20674553
CCND1cyclin D1595Colon CancerSW-480----The expression level of beta-catenin and one of its transcriptional targets, cyclin D1, were suppressed by Antofine in SW480 cells.20674553
CCNE1cyclin E1898Colon cancerHCT-116----Antofine dose-dependently suppressed cyclin E expression in HCT 116 cells.20674553
CDK4cyclin-dependent kinase 41019Colon cancerHCT-116----Antofine dose-dependently suppressed CDK4 expression in HCT 116 cells.20674553
CTNNBIP1catenin, beta interacting protein 156998Colon cancerHCT-116----The expression level of beta-catenin and one of its transcriptional targets, cyclin D1, were suppressed by Antofine in HCT 116 cells.20674553
CTNNBIP1catenin, beta interacting protein 156998Colon CancerSW-480----The expression level of beta-catenin and one of its transcriptional targets, cyclin D1, were suppressed by Antofine in SW480 cells.20674553
PARP1poly (ADP-ribose) polymerase 1142Colon cancerHCT-116----Antofine or TNF-alpha alone showed marginal effects on the cleavage of PARP.20674553
TNFtumor necrosis factor7124Colon cancerHCT-116----Antofine treatment markedly enhanced TNF-alpha-induced apoptotic cell death.20674553

 






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