NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Ginsenoside Rg3

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581Colon cancerHCT-116----Combination treatment of Rg3 and docetaxol substantially increased levels of Bax in HCT-116 cells.19471891
BAXBCL2-associated X protein581Colon CancerSW-460----Combination treatment of Rg3 and docetaxol substantially increased levels of Bax in SW-460 cells.19471891
BCL2B-cell CLL/lymphoma 2596Colon cancerHCT-116----Combination treatment of Rg3 and docetaxol substantially inhibited levels of Bcl-2 in HCT-116 cells.19471891
BCL2B-cell CLL/lymphoma 2596Colon CancerSW-460----Combination treatment of Rg3 and docetaxol substantially inhibited levels of Bcl-2 in SW-460 cells.19471891
BIRC2baculoviral IAP repeat containing 2329Colon cancerHCT-116----Combination treatment of Rg3 and docetaxol substantially inhibited levels of cIAP-1 in HCT-116 cells.19471891
BIRC2baculoviral IAP repeat containing 2329Colon CancerSW-460----Combination treatment of Rg3 and docetaxol substantially inhibited levels of cIAP-1 in SW-460 cells.19471891
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon cancerHCT-116----Combination treatment of Rg3 and docetaxol substantially increased levels of Caspase-3 in HCT-116 cells.19471891
CASP3caspase 3, apoptosis-related cysteine peptidase836Colon CancerSW-460----Combination treatment of Rg3 and docetaxol substantially increased levels of Caspase-3 in SW-460 cells.19471891
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon cancerHCT-116----Combination treatment of Rg3 and docetaxol substantially increased levels of Caspase-9 in HCT-116 cells.19471891
CASP9caspase 9, apoptosis-related cysteine peptidase842Colon CancerSW-460----Combination treatment of Rg3 and docetaxol substantially increased levels of Caspase-9 in SW-460 cells.19471891
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Colon CancerSW-460----Constitutive activation of NF-kB was observed in colon cancer cells, and treat-ment with Rg3 (0-100 µM) and docetaxel (1-50 nM)concentration-dependently inhibited NF-kB activity with IC50values of about 100 µM for Rg3 or 10 nM for docetaxel.19471891
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 14790Colon cancerHCT-116----Constitutive activation of NF-kB was observed in colon cancer cells, and treat-ment with Rg3 (0-100 µM) and docetaxel (1-50 nM)concentration-dependently inhibited NF-kB activity with IC50values of about 100 µM for Rg3 or 10 nM for docetaxel.19471891
XIAPX-linked inhibitor of apoptosis331Colon cancerHCT-116----Combination treatment of Rg3 and docetaxol substantially inhibited levels of XIAP in HCT-116 cells.19471891
XIAPX-linked inhibitor of apoptosis331Colon CancerSW-460----Combination treatment of Rg3 and docetaxol substantially inhibited levels of XIAP in SW-460 cells.19471891

 






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