NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: 4'-Hydroxy-3,5-dimethoxystilbene

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
ATF2activating transcription factor 21386Colon CancerHT-2922.4 µmol/L---Pterostilbene blocked the phosphorylation and nuclear translocation of p38 and ATF2induced by cytokine mixture, providing evidence for the involvement of the p38 MAPK-ATF2pathway for the anti-inflammatory action of pterostilbene in HT-29 colon cancer cells.19549798
CCND1cyclin D1595Colon CancerHT-2922.4 µmol/L---Pterostilbene inhibited the growth of HT-29 cells and altered markers of cellular proliferation and apoptosis, as shown by lower protein levels of cyclin D1.19549798
COX-2cytochrome c oxidase subunit II4513Colon CancerHT-2922.4 µmol/L---Pterostilbene down-regulates mRNA levels of inflammatory genes COX-2.19549798
IL1Binterleukin 1, beta3553Colon CancerHT-2922.4 µmol/L---Pterostilbene down-regulates mRNA levels of proinflammatory cytokines IL-1beta.19549798
MAPK1mitogen-activated protein kinase 15594Colon CancerHT-2922.4 µmol/L---Pterostilbene blocked the phosphorylation and nuclear translocation of p38 and ATF2induced by cytokine mixture, providing evidence for the involvement of the p38 MAPK-ATF2pathway for the anti-inflammatory action of pterostilbene in HT-29 colon cancer cells.19549798
MYCv-myc myelocytomatosis viral oncogene4609Colon CancerHT-2922.4 µmol/L---Pterostilbene inhibited the growth of HT-29 cells and altered markers of cellular proliferation and apoptosis, as shown by lower protein levels of c-Myc.19549798
NOS2nitric oxide synthase 2, inducible4843Colon CancerHT-2922.4 µmol/L---Pterostilbene down-regulates mRNA levels of inflammatory genes iNOS.19549798
TNFtumor necrosis factor7124Colon CancerHT-2922.4 µmol/L---Pterostilbene down-regulates mRNA levels of proinflammatory cytokines TNF-alpha.19549798

 






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