NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: (R)-tylophorine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CCNB1cyclin B1891HepatomaHep G2---237±32 nMIn asynchronized HepG2a slight decrease in cyclin B1 level was noticed.19501048
CCNB1cyclin B1891Nasopharyngeal carcinoma cellsHONE-1---114±6 nMIn asynchronized HONE-1 slight decrease in cyclin B1 level was noticed.19501048
CCNB1cyclin B1891CarcinomaNUGC-3---134±9 nMIn asynchronized NUGC-3 slight decrease in cyclin B1 level was noticed.19501048
CDK2cyclin-dependent kinase 21017HepatomaHep G2---237±32 nMIn asynchronized HepG2 a slight decrease in Cdk2 level was noticed.19501048
CDK2cyclin-dependent kinase 21017Nasopharyngeal carcinoma cellsHONE-1---114±6 nMIn asynchronized HONE-1 a slight decrease in Cdk2 level was noticed.19501048
CDK2cyclin-dependent kinase 21017CarcinomaNUGC-3---134±9 nMIn asynchronized NUGC-3 a slight decrease in Cdk2 level was noticed.19501048
CYC3Bcyclin-A2-2831001HepatomaHep G2---237±32 nMIn asynchronized HepG2 , cyclin A2 level was significantly lower with tylophorine treatment than with DMSO and dehydro-tylophorine treatment. 19501048
CYC3Bcyclin-A2-2831001Nasopharyngeal carcinoma cellsHONE-1---114±6 nMIn asynchronized HONE-1 , cyclin A2 level was significantly lower with tylophorine treatment than with DMSO and dehydro-tylophorine treatment. 19501048
CYC3Bcyclin-A2-2831001CarcinomaNUGC-3---134±9 nMIn asynchronized NUGC-3 , cyclin A2 level was significantly lower with tylophorine treatment than with DMSO and dehydro-tylophorine treatment. 19501048

 






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