NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Zhankuic acid C

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
PARP1poly (ADP-ribose) polymerase 1142Colon CancerHT-29----nuclear full length PARP was decreased, and the cleaved form of PARP in the nuclei was significantly increased after 48 h of treatment .Similar results were obtained for the inhibition of Bcl-2 and pro-caspase-3 expression. During the apoptosis, PARP has been reported to be proteolyzed directly by active caspase-3, resulting in the inactivation of PARP for DNA repair.19477064

 






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