NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Xanthohumol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
NOS2nitric oxide synthase 2, inducible4843Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.712.9 µM---Nitric oxide (NO) synthase (iNOS) and consequently, enhance the generation of NO. Generally, NO is an important signaling molecule, long-term elevated levels of NO, however, have been linked to early steps in carcinogenesis.It cause inhibition of lipopolysaccharide (LPS)-mediated induction of inducible nitric oxide synthase , which is an anti-inflammatory mechanis.Phytochemistry Reviews 1: 369-377, 2002

 






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