NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Xanthohumol

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
CYPIA1cytochrome P450, family 1, subfamily A, polypeptide 11543Murine monocyte/macrophage line derived from ascitic tumour induced with Abelson leukaemai virusRAW264.70.02 µM---The chalcone xanthohumol isolated from beer potently inhibited Cyp1A activity, with IC50 0.02 µM.Cyp1A, which is e.g. involved in the activation of carcinogens from grilled meat, as a model phase 1 enzyme, and measured the potential of beer constituents to inhibit its enzymatic activity.Phytochemistry Reviews 1: 369-377, 2002

 






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