NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Wogonin

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
BAXBCL2-associated X protein581sarcomaS180----After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%.After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could increase the levels of bax mRNA and bax protein in a concentration-dependent manner.16755005
BCL2B-cell CLL/lymphoma 2596sarcomaS180----After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%. After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could lower the level of bcl-2 mRNA and bcl-2 protein.16755005
CDK7cyclin-dependent kinase 71022T-cell LeukemiaCEM12.3 µM---CDK7 is a component of the transcription factor TFIIH, which phosphorylates Ser5 residues in the heptad repeats of the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII) to facilitate transcription initiation.21776020
CDK9cyclin-dependent kinase 91025T-cell LeukemiaCEM0.19 µM---Wogonin preferentially inhibits CDK9 in malignant compared with normal lymphocytes.21776020
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170Adult T-cell leukemia (ATL) HTLV-1-SP----Wogonin downregulates Mcl-1 protein expression in malignant cells.21776020
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170Colon cancerHCT-116----Wogonin downregulates Mcl-1 protein expression in malignant cells.21776020
MCL1myeloid cell leukemia sequence 1 (BCL2-related)4170T-cell LeukemiaCEM----Wogonin downregulates Mcl-1 protein expression in malignant cells.21776020
TP53tumor protein p537157sarcomaS180----After the seven-day treatments by the route of i.v., wogonin (20, 40mg/kg) had significant inhibitory effect on the growth of inoculated S180 in mice. The inhibitory rates was 34.24%. After mice with S180 were treated with wogonin (20,40mg/kg) seven times intravenously,wogonin could increase the levels of p53 mRNA dramatically in a concentration-dependent manner.16755005

 






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