NPACT- Naturally occuring Plant based Anticancerous Compound-Activity-Target DataBase

Compound: Vinblastine

TargetsGene NameGene IDCancerCell LinesIC50ED50EC50GI50RemarkReferences
JUNjun proto-oncogene3725Cervical CarcinomaKB-3----Vinblastine treatment in all cell lines examined causes a robust increase in c-Jun protein expression and phosphorylation and a corresponding increase in activator protein-1 (AP-1) transcriptional activity. We show in KB-3 carcinoma cells that this is due to a strong autoamplification loop involving the proximal AP-1 site in the c-Jun promoter, resulting in highly increased c-Jun mRNA and c-Jun protein.18094076

 






Copyright © 2012. Subhash M. Agagrwal. All Rights Reserved.